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The emergence of induced pluripotent stem cells (iPS) has offered unprecedented opportunities in developmental biology and regenerative medicine. Generated from patient cells, iPS maintains their genetic features, allowing deciphering healthy or pathological processes in a personalized fashion. Applied to hematopoiesis, this technology holds enormous promises towards generating transplantable hema

https://www.wcmm.lu.se/human-ossicles-ips-hsc-development-and-leukemia-modeling - 2025-10-25

Introduction | Chronic inflammation in autoimmune diseases is driven by resident T cells and a breakdown in immune tolerance. Systemic factors often complicate the study of local antigen presentation; however, juvenile idiopathic arthritis (JIA) provides a unique model due to its joint-specific inflammation. While innate immune-driven T-cell activation has been observed in JIA, the roles of autoan

https://www.wcmm.lu.se/local-breach-tolerance-understanding-process-chronicity-autoimmune-disease - 2025-10-25

Why only certain animal species can regenerate complex structures remains an important and open question. Technological advances have now opened the door to studying the molecular mechanisms of highly regenerative species, like salamanders. A unique aspect of regeneration in these species is that fully differentiated cells are coaxed to re-enter the cell cycle. This reentry is typically blocked by

https://www.wcmm.lu.se/elucidating-underlying-mechanisms-cell-cycle-regulation-limb-regeneration - 2025-10-25

Multi-drug resistant bacterial infections, such as Pseudomonas aeruginosa represent a significant global health care burden and disproportionately impact patients who are immuno-comprised, which make them more susceptible to opportunistic pathogens. These infections impact a broad range of patients, including those with chronic diseases such as diabetes, cancer, organ transplant recipients, and th

https://www.wcmm.lu.se/apical-out-human-airway-organoids-chip-derived-ipscs-studying-bacterial-infections - 2025-10-25

Lung transplantation is currently the only treatment option for end-stage lung disease. Despite procedural improvements, primary graft dysfunction (PGD) remains a leading cause of early mortality and chronic allograft dysfunction, leading to poor long-term survival rates. Mesenchymal stem/stromal cell (MSC) based therapies have the potential to ameliorate injured donor lungs and to improve the res

https://www.wcmm.lu.se/advanced-engineered-msc-therapies-lung-transplantation - 2025-10-25

RNA based therapeutics, e.g., siRNA, antisense, mRNA- and CRISPR-based drugs, are a novel class of drugs that that are potential ideal precision drugs for oncology given their highly specific and targeted nature. However, cytosolic delivery remains the major obstacle to macromolecular RNA drug development.In my (Anders Wittrup) lab we have developed several new techniques both for detection and qu

https://www.wcmm.lu.se/discovery-and-characterization-cell-biological-barriers-therapeutic-rna-delivery - 2025-10-25

Back to news archive2017-11-30: Grants awarded from the Swedish Research Council (VR) and the Swedish Cancer Society (Cancerfonden)Congratulations to the following WCMM researchers who have recently received grants:ANJA MEISSNER, who received 800 tKr/year (2018-2020) from the Swedish Research Council (VR-M) for the project “The communication between Sphingosine-1-phosphate signaling and the Renin-

https://www.wcmm.lu.se/grant-award - 2025-10-25

Type 2 diabetes mellitus (T2D) and Parkinson’s Disease (PD) are two major disorders associated with aging, and their prevalence is steadily increasing worldwide. These two conditions share several important features: they have a complex multifactorial pathogenesis, encompass different disease subtypes, and are associated with degenerative changes in several organs. Individuals with T2D are reporte

https://www.wcmm.lu.se/translational-development-interface-between-diabetes-and-parkinsons-disease - 2025-10-25

Congential heart disease affects approximately one percent of all children born worldwide. This multidisciplinary project will combine novel 3D imaging, using synchrotron-based phase contrast micro-CT, with cell and molecular biology for improved understanding of congenital heart defects and cardiovascular function. The primary focus will be the importance of basement membranes for cardiovascular

https://www.wcmm.lu.se/importance-basement-membranes-cardiovascular-development-and-disease - 2025-10-25

Purpose | Our study seeks to contribute novel insights into the development of novel HSC-based regenerative strategies for multiple sclerosis (MS) using our recently defined connection point between peripheral and-CNS immunity. We aim to develop a better mechanistic understanding of this autologous cell therapy, keeping clinical translation in mind, thereby offering new hope for individuals affect

https://www.wcmm.lu.se/autologous-bone-marrow-transplantation-treatment-multiple-sclerosis-endogenous-hematopoietic-stem - 2025-10-25

The Stars of the Brain Iben Lundgaard, Associate Professor | LUNDGAARD LAB Through Synchrotron Eyes: A Glimpse into Early Heart Development Niccolò Peruzzi, Postdoc | TRAN LUNDMARK LAB Alpha Synuclein Galaxy Oksana Tymoshchuk, Research Associate | LUNDGAARD LAB Shortcut Karin Tran Lundmark, Principal Investigator | TRAN LUNDMARK LAB Developing Chick Embryo Nika Gvazava, PhD student | WAGNER LAB Au

https://www.wcmm.lu.se/whats/wcmm-fusion-2025-where-science-meets-art/where-science-meets-art - 2025-10-25

Back to news archiveTandem researchers Smith & MeissnerRead about Gustav Smith and Anja Meissner in LUM magasin nr 6, 2017 .

https://www.wcmm.lu.se/tandem-researchers-smith-meissner - 2025-10-25

Back to news archiveThe calls for our first two tenure track research positions (Associate Senior Lecture level) within WCMM LU are now closed as of February 1st 2016.We are happy to announce a large interest of applicants for the two positions Molecular Medicine: Regeneration and repair in the nervous system and Molecular Medicine: Regeneration and repair in the cardiovascular system, respectivel

https://www.wcmm.lu.se/first-call-tenure-track-positions-closed - 2025-10-25

Nika Gvazava, PhD student | WAGNER LAB The storyTissue clearing is a ground breaking technique that has transformed our ability to image complex biological structures in 3D, including visualization of intricate cellular architectures in their native environment with high spatial resolution. It involves selectively reducing the amount of light-scattering and absorption molecules (e.g lipids) from b

https://www.wcmm.lu.se/developing-chick-embryo - 2025-10-25

Iben Lundgaard, Associate Professor | LUNDGAARD LAB The storyThis image shows astrocytes contacting and wrapping themselves around cerebral blood vessels in the pig brain.Research areaThe glymphatic brain clearance system, which we believe is important for preventing development of diseases, such as Alzheimer’s disease.Image descriptionAstrocytes, glia cells, in light blue and blood vessels in mul

https://www.wcmm.lu.se/stars-brain-0 - 2025-10-25

Oksana Tymoshchuk, Research Associate | LUNDGAARD LAB The storyThis was an experiment with chronic fibrils, during which we bilaterally injected fibrils into the brains of mice and observed these mice over a period of six months. The image was taken six months after the fibril injection. It was a collaborative project with universities in the United States. Together, we are taking small steps towa

https://www.wcmm.lu.se/alpha-synuclein-galaxy - 2025-10-25

Back to news archiveResearchers at Lund University and Region Skåne are invited to submit Letters of Intent to LU WCMM regarding topics for new tenure track positions. The submission deadline is Monday, March 21 24.00. For all information, please see the link below:

https://www.wcmm.lu.se/invitation-submit-letters-intent - 2025-10-25

Bryan Falcones, Postdoc | WESTERGREN THORSSON LAB The storyHidden within the intricate architecture of lung tissue lies a chemical mosaic, a story told by the distribution of elements that govern health and disease. Using the X-ray imaging capabilities at MAX IV laboratory, researchers have illuminated this unseen world with unprecedented detail. At the heart of this process is the synchrotron, a

https://www.wcmm.lu.se/elemental-breath-chemical-mosaic-lung-tissue - 2025-10-25

Poojaswini Thimmaraya Reddy, MSc student | CONSIGLIO LAB The storyThe story I want to tell with this art piece is about the complex and varied immune profiles of different women, focusing on the differences in their cytokine levels in serum and follicular fluid. Cytokines are crucial signaling molecules in the immune system that play a key role in inflammation, immune response, and tissue repair.

https://www.wcmm.lu.se/cytokine-heatmap - 2025-10-25

Kelley Swanberg, Postdoc | LUNDGAARD LAB The storyAn intricate web of disparate experimental, signal acquisition, processing and analysis methods within in vivo proton magnetic resonance spectroscopy converges beautifully to depict the cortical metabolic similarities between two distinct species.Research areaThe glymphatic brain clearance system, in vivo functional and metabolic signatures of glym

https://www.wcmm.lu.se/symmetry - 2025-10-25